Protocol VPROTOCOL V

Protocol V Hair Stack — Breo S3, RU58841, GHK-Cu & Growth Signals

Thu Dec 11 2025 00:00:00 GMT+0000 (Coordinated Universal Time)

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Educational only. Research log, not medical advice. No treatment, cure, or guarantees implied.

Protocol V Hair Protocol

Goal: Tactical scalp defense + follicle support using four pillars:

  1. Local androgen control (RU58841 / KX-826)
  2. Inflammation & repair (GHK-Cu / AHK-Cu, Breo S3)
  3. Systemic growth/recovery signals (GH-axis research)
  4. Structural support (collagen, minerals, joint/skin stack)

This is how I organize the whole system so it’s repeatable and you can see what happens over weeks, not just days.

Tools & Signals

Hardware

  • Breo S3 — 850–860 nm near-infrared scalp device
  • 0.5 mm Derma Roller — surface micro-channels (lighter stimulus)
  • 1.5 mm Microneedling Device — deeper mechanical signal (use sparingly, recovery dependent)

Topical Research Compounds

Injectable / Systemic Research Signals

All of this is research-only, not dosing advice.

Supplement Stack (Systemic Support)

This is what I actually run, organized so it matches the hair routine. Check labs and contraindications with your clinician.

Morning — “Scaffold + Circulation” Block

  • Multi-Collagen (Types I–V)
    • Structural support for skin, ligaments, and hair shaft.
  • Silica / Orthosilicic Acid
    • Supports collagen cross-linking and hair/nail structure.
  • Vitamin C (with collagen)
    • Required cofactor for collagen synthesis; I pair it with collagen.
  • Glucosamine + Chondroitin
    • Joint support and connective tissue comfort, especially with heavier training.
  • Hyaluronic Acid
    • “Lubrication” support for joints and skin hydration signal.
  • Vitamin D3 + K2
    • Overall metabolic and bone support; I treat this as a baseline health lever, not just for hair.
  • Omega-3 (Fish Oil)
    • Systemic inflammation control — important when you’re hitting the scalp with physical and light signals.
  • Zinc (only if labs justify it)
    • Immune and skin support; too much can cause issues, so I don’t blindly mega-dose.

Evening — “Wind-Down + Recovery” Block

  • Magnesium Glycinate
    • Relaxation + sleep support; I avoid harsh laxative forms.
  • Biotin (moderate dose)
    • Hair/nail support. I avoid extreme doses because they can interfere with certain lab tests.
  • Additional Hyaluronic Acid (optional)
    • If joints/skin feel dry with heavy training blocks.
  • Collagen (second dose, optional)
    • If total collagen intake is low from food.

The big picture: scalp health rides on whole-system health. Sleep, blood pressure, lipids, and training load all matter as much as the fancy chems.

How the System Works (High Level)

  • RU58841 / KX-826 → local androgen receptor blockade
    Goal: reduce DHT signaling at the follicle without changing systemic hormones.
  • GHK-Cu / AHK-Cu → repair & remodeling
    These peptides are studied for collagen production, wound healing, and anti-inflammatory effects in skin and scalp models.
  • Breo S3 (850–860 nm) → light-based mitochondrial support
    Deep red/near-infrared wavelengths are studied for increasing local blood flow and mitochondrial output in hair follicles, which may support growth in some models.
  • Microneedling/derma rolling → mechanical micro-injury
    Creates micro-channels and a wound-healing cascade that can increase local growth factors and absorption of topicals.
  • GH-axis support (Tesamorelin + Ipamorelin) → recovery capacity
    I treat this as “terrain support”: better healing, better sleep, better training recovery — which then supports more frequent scalp work without overdoing it.

Daily Templates

I run three daily templates and then build the week from them:

  • Schedule A: Normal day (no needle / roller)
  • Schedule B: 0.5 mm derma roller day
  • Schedule C: 1.5 mm microneedling day

You can run this with or without a GH-axis stack. If you’re not on a GH-axis research protocol, dial back needling frequency and intensity.

Schedule A — “Baseline” (No Needle / Roller)

Morning

  • Morning GHRP (Ipamorelin) — fasted
  • Morning supplement block (collagen, silica, Vitamin C, glucosamine/chondroitin, HA, D3/K2, omega-3, zinc if needed)
  • Breo S3 + Minoxidil
    • Apply minoxidil to scalp (target zones + overall coverage).
    • Run Breo S3 for ~8 minutes over Target Zone 1 and then move across the whole head.
    • After the session, wipe/dispose residual minoxidil so it’s not sitting on skin all day.

Afternoon

  • Breo S3 + RU58841 (or KX-826 on key zones)
    • Apply RU58841 solution (or KX-826 on highest-risk areas).
    • Breo S3 over Target Zone 2 for 8 minutes minimum.
  • Optional: A second minoxidil application at least 1 hour separated from RU/topical session if your scalp tolerates it.

Evening

  • Evening GHRH (Tesamorelin-type analog) — fasted

  • Evening GHRP (Ipamorelin) — optional second/third daily dose

  • Injectable GHK-Cu — low dose for systemic skin/scalp inflammation research

  • Evening supplement block (magnesium glycinate, biotin, optional collagen/HA)

  • Breo S3 + Topical GHK-Cu

    • Apply topical GHK-Cu to target areas.
    • Run Breo S3 for 8 minutes on Target Zone 3, then sweep all zones.

  • 20 minutes later:

    • Apply NeuroGAN GHK-Cu pastes/creams designed to stay on overnight.
    • For areas with hair, I use a soft toothbrush to work paste through hair down to the scalp.

Schedule B — Derma Roller Day (0.5 mm)

Schedule B = Schedule A + 0.5 mm roller in the evening.

Morning / Afternoon
Same as Schedule A.

Evening

  1. Research chems:

    • GHRH (Tesamorelin analog)
    • GHRP (Ipamorelin)
    • Injectable GHK-Cu
    • Evening supplements

  2. 0.5 mm Derma Roller

    • Disinfect roller (alcohol or appropriate disinfectant, let it dry).
    • Gently roll over targeted areas in multiple directions (up/down, side/side, diagonals).
    • No aggressive pressure; the goal is pink, not shredded.

  3. 20 minutes after rolling → AHK-Cu

    • Apply AHK-Cu to rolled zones.
    • Use fingers to gently massage in; no scraping or heavy rubbing.

  4. At least 1 hour later → Optional GHK-Cu + Breo

    • Optional:
      • Breo S3 with topical GHK-Cu for ~8 minutes per target zone.
      • Then, 20 minutes after that, apply GHK-Cu pastes/creams for overnight contact.

Schedule C — Microneedling Day (1.5 mm)

Schedule C = Schedule A + 1.5 mm microneedling (heavier signal).

Morning / Afternoon
Same as Schedule A.

Evening

  1. Research chems:

    • GHRH (Tesamorelin analog)
    • GHRP (Ipamorelin)
    • Injectable GHK-Cu
    • Evening supplements

  2. Microneedling (1.5 mm)

    • Disinfect device.
    • Work over target zones at multiple angles (vertical, horizontal, diagonal).
    • Stop at even pinpoint redness, not full bleeding.
    • This is a deeper wounding signal; recovery matters.

  3. 20 minutes later → AHK-Cu spray

    • Apply AHK-Cu in spray or drop form to all microneedled areas.
    • Lightly press in; don’t scrub.

  4. ~1 hour later → Breo + optional GHK-Cu

    • Breo S3 with topical GHK-Cu for 8 minutes per target zone.
    • 20 minutes after Breo, apply overnight GHK-Cu pastes/creams.
    • Use a toothbrush in hair-dense zones to get product directly on scalp.

Weekly Rotation

I use the daily templates to structure the week.

First 60 Days (while running GH-axis stack)

  • Sunday: Schedule C (Microneedle)
  • Monday: Schedule A
  • Tuesday: Schedule B (0.5 mm roller)
  • Wednesday: Schedule C
  • Thursday: Schedule A
  • Friday: Schedule B
  • Saturday: Schedule A

This gives 2 microneedling days + 2 roller days per week, supported by GH-axis recovery signals.

After 60 Days, or if NOT Using GH-Axis Stack

Dial needling frequency down slightly:

  • Sunday: Schedule C (Microneedle)
  • Monday: Schedule A
  • Tuesday: Schedule B (0.5 mm roller)
  • Wednesday: Schedule A
  • Thursday: Schedule B
  • Friday: Schedule A
  • Saturday: Schedule A

This keeps microneedling at ~1× per week and roller at 1–2× per week, which is closer to what many dermatology-style protocols use when recovery support is more limited.

Why 8–12 Minutes per Breo S3 Zone?

The Breo S3 uses 850–860 nm near-infrared light — a range often studied for:

  • Increasing local blood flow
  • Supporting mitochondrial ATP production
  • Modulating inflammation in skin and scalp models

Most photobiomodulation research targets a dose window (J/cm²) rather than just “time,” but in practice, 8–12 minutes per zone on the S3 is how I aim to hit a reasonable dose without cooking the scalp or making the routine impossible to stick with daily.

Key points:

  • I treat 8 minutes as minimum, 12 minutes as heavy dose.
  • I avoid stacking infinite extra sessions; more is not always better.
  • I pair Breo with active topicals (minoxidil, RU/KX-826, GHK-Cu) so light and chemistry are pointed at the same problem: circulation + signaling at the follicle.

Why Microneedle 2×/Week (When GH-Axis is On Board)

Microneedling at 1.5 mm is essentially controlled injury:

  • Breaks through more of the epidermis.
  • Triggers wound-healing cascades and local growth factors.
  • Increases penetration of topicals placed after the initial acute phase.

When a GH-axis stack is active (Tesamorelin + Ipamorelin + GHK-Cu):

  • Recovery from micro-injury tends to feel faster.
  • You can often tolerate slightly higher frequency (like 2×/week) if sleep, protein, and calories are on point.

If recovery lags:

  • Drop to 1×/week microneedling or rotate to more roller days.
  • Watch for persistent redness, flaking, or burning — signs that frequency/intensity is too high.

If you’re not using any GH-axis research:

  • Start more conservatively:
    • Microneedling 1×/week
    • Roller 1–2×/week
    • Plenty of Schedule A days between.

Why Experiment with KX-826 on Top of RU58841?

RU58841 is already a well-known local androgen receptor blocker used in research on scalp DHT.
KX-826 (Pyrilutamide):

  • Designed as a topical AR antagonist with its own binding profile.
  • Early data suggests it stays relatively local and may have a different irritation/tolerability profile than RU for some people.
  • I’m interested in whether certain zones (like temples/crown) respond better when KX-826 is used there while RU covers the rest.

My current approach:

  • RU58841 as the base layer for most of the scalp.
  • KX-826 on highest-risk or most stubborn zones, especially in periods where I’m watching for differences in density over 3–6 month windows.

Protocol V Takeaways

  • Don’t guess — systematize.
    Use Schedule A/B/C and the weekly map so you can actually tell if your stack is doing anything.

  • Match signals to recovery.
    If sleep, food, or stress are off, dial back microneedling and topicals rather than pushing harder.

  • Keep it research-only and documented.
    Track photos, notes, and training load so you know what changed when, instead of blaming or praising the wrong signal.

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