Protocol VPROTOCOL V

RP&D

Protocol V — Reset Stack (Metabolic + Mitochondrial Realignment)

RP&DMar 18, 2026research • reset • mitochondria • metabolism • peptides • neuro • veterans
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🔗 Required System Context (Read First)

Before running or interpreting this system, understand the timing layers it sits on:

This stack assumes:

  • Electrolytes are already stabilized
  • Daily performance + recovery timing is in place

If those are off, this system will feel inconsistent.

RP&D Overview

This is a reset stack, not a growth stack.

The purpose is to:

  • Reduce signal noise after heavy anabolic or IGF exposure
  • Restore metabolic flexibility
  • Improve mitochondrial efficiency
  • Stabilize nervous system output
  • Maintain performance without forcing growth signaling

This document exists to track:

  • timing
  • dosing
  • reconstitution
  • draw units
  • frequency
  • system logic

Stack Duration

Typical Length: 4–8 weeks

Context:

  • Post-growth phase
  • Post-IGF exposure
  • Fatigue, poor sleep, or unstable output

① MORNING (FASTED)

AOD-9604

Reconstitution:

  • 0.25 mL acetic acid + 1.75 mL bac water (total 2 mL)

Dose:

  • 300 mcg → 12 units

Frequency:

  • Daily

Timing:

  • Immediately upon waking (fasted)

Note:

  • Standardized here at 300 mcg/day as the max-effective anchor for internal consistency

MOTS-C

10 mg vial

Reconstitution:

  • 2 mL bac water

Concentration:

  • 5 mg/mL

Reference draws (U-100):

  • 2 mg = 40 units
  • 3 mg = 60 units
  • 4 mg = 80 units
  • 5 mg = 100 units

40 mg vial

Reconstitution:

  • 3 mL bac water

Concentration:

  • ~13.3 mg/mL

Reference draws (U-100):

  • 2 mg = 15 units
  • 3 mg = 23 units
  • 4 mg = 30 units
  • 5 mg = 38 units

Preferred Dose:

  • 2–5 mg

Frequency:

  • 2–3× per week (NOT daily)

Timing:

  • Morning fasted

⭐ Reset Protocol Anchor:

  • 5 mg → 38 units
  • 3× per week

👉 Daily MOTS = fatigue + signal blunting

5-Amino-1MQ

10 mg vial

Reconstitution:

  • 2 mL bac water

Concentration:

  • 5 mg/mL

Reference draws (U-100):

  • 2 mg = 40 units

50 mg vial

Reconstitution:

  • 3 mL bac water

Concentration:

  • ~16.7 mg/mL

Reference draws (U-100):

  • 2 mg = ~12 units

Preferred Dose:

  • 2 mg

Frequency:

  • Daily

Timing:

  • Morning fasted

SLU-PP-332 (capsules)

Dose:

  • 50 mg caps

Frequency:

  • Daily

Ramp:

  • Days 1–3 → 1 cap
  • Days 4–6 → 2 caps
  • Then → 3 caps

Timing:

  • Morning or pre-workout

NAD⁺

Reconstitution:

  • 500 mg vial → 1.0 mL bac water

Concentration:

  • 500 mg/mL

Reference draws (U-100):

  • 100 mg = 20 units
  • 150 mg = 30 units
  • 200 mg = 40 units
  • 250 mg = 50 units

Dose:

  • 100–250 mg per session

Frequency:

  • 2–4× per week

Timing:

  • Morning only

Notes:

  • Start lower if nausea, fatigue, or overstimulation shows up
  • This reset stack uses the recovery/performance lane, not the longevity maintenance lane
  • Best treated like a pulsed restoration tool, not a daily baseline

AICAR

Reconstitution:

  • 50 mg → 2 mL

Dose:

  • 10–20 mg → 40–80 units

Frequency:

  • Training days only (2–4×/week)

Timing:

  • 20–30 min pre-training OR AM fasted

🧠 NEURO STACK

Semax (CMAX)

Reconstitution:

  • 10 mg → 2 mL

Concentration:

  • 5 mg/mL

Reference draws (U-100):

  • 250 mcg = 5 units
  • 500 mcg = 10 units

Dose:

  • 250–500 mcg

Frequency:

  • Daily

Timing:

  • Morning

Selank

Reconstitution:

  • 10 mg → 2 mL

Concentration:

  • 5 mg/mL

Reference draws (U-100):

  • 250 mcg = 5 units
  • 500 mcg = 10 units

Dose:

  • 250–500 mcg

Frequency:

  • Daily

Timing:

  • Afternoon / early evening

👉 Split matters:

  • Semax = stimulation / execution
  • Selank = calming / stabilization

🌙 NIGHT / RECOVERY

DSIP (Delta Sleep-Inducing Peptide)

Reconstitution:

  • 5 mg → 2.0 mL total volume

Concentration:

  • 2.5 mg/mL

Reference draws (U-100):

  • 300 mcg = 12 units
  • 900 mcg = 36 units

Dose:

  • 300–900 mcg

Frequency:

  • Nightly during course

Timing:

  • 30–60 minutes pre-sleep

Cycle length:

  • 5–14 days ON

Time OFF:

  • 1–2+ weeks OFF

Carb guidance:

  • Keep pre-bed intake clean; avoid heavy carbs near dosing

Storage note:

  • Refrigerate after reconstitution

Epitalon

Reconstitution:

  • 10 mg → 2 mL

Concentration:

  • 5 mg/mL

Reference draws (U-100):

  • 1 mg = 20 units
  • 2 mg = 40 units

Dose:

  • 1–2 mg

Frequency:

  • Daily

Timing:

  • Night

Cycle length:

  • 10–20 days

Pinealon

Reconstitution:

  • 10 mg → 2 mL

Dose:

  • 1–2 mg → 20–40 units

Frequency:

  • Daily

Timing:

  • Night

📅 WEEKLY / SYSTEMIC

Retatrutide

Reconstitution:

  • 30 mg → 3 mL

Concentration:

  • 10 mg/mL

Reference draw (U-100):

  • ~0.57 mg = ~6 units

Dose:

  • ~0.57 mg

Frequency:

  • Daily (microdose)

Timing:

  • Same time daily (AM preferred)

Notes:

  • Daily microdose version is the performance extrapolation lane
  • Used to smooth appetite suppression and reduce peak-driven side effects while supporting insulin sensitivity

Cagrilintide

Reconstitution:

  • 5 mg → 2 mL

Concentration:

  • 2.5 mg/mL

Reference draws (U-100):

  • 0.25 mg = 10 units
  • 0.5 mg = 20 units

Dose:

  • 0.25–0.5 mg

Frequency:

  • 1–3× per week

Timing:

  • Same day/time weekly (AM preferred)

⭐ Reset Protocol Anchor:

  • 0.25–0.5 mg → 10–20 units
  • 3× per week

Guardrails (READ THIS):

  • Start at 0.25 mg (10 units) — do not jump straight to 0.5 mg
  • If performance drops → frequency is too high
  • If appetite disappears completely → too aggressive
  • If nausea shows up → reduce frequency first, not dose

Notes:

  • This is adherence control, not starvation
  • Longer-acting than most people expect → effects accumulate across the week
  • Running this at 3×/week is more aggressive than typical use — monitor training output, recovery, and food intake closely

FOXO4-DRI

Reconstitution:

  • 10 mg → 2 mL

Concentration:

  • 5 mg/mL

Reference draws (U-100):

  • 5 mg = 100 units
  • 10 mg = 200 units

Current Testing Range:

  • 5 mg → 100 units
  • 2× per week

Frequency:

  • Pulse only (NOT daily)

Timing:

  • AM preferred (keep consistent)

Notes:

  • This is a controlled senolytic signaling lane — not a baseline compound
  • More is not better → excessive frequency = unnecessary stress signaling
  • Treat like a “system reset trigger,” not a daily input

ARA-290

5 mg vial

Reconstitution:

  • 2 mL bac water

Concentration:

  • 2.5 mg/mL

Reference draws (U-100):

  • 2 mg = 80 units
  • 3 mg = 120 units
  • 4 mg = 160 units

10 mg vial

Reconstitution:

  • 3 mL bac water

Concentration:

  • ~3.33 mg/mL

Reference draws (U-100):

  • 2 mg = 60 units
  • 3 mg = 90 units
  • 4 mg = 120 units

Dose:

  • 2–4 mg

Frequency:

  • Daily OR 2–3× per week if used as support inside the reset stack

Timing:

  • AM preferred

🔴 FINAL SYSTEM LOGIC

DAILY CORE

  • AOD
  • 5-Amino
  • SLU
  • Semax (AM)
  • Selank (PM)
  • Retatrutide
  • Pinealon
  • Epitalon (cycle)

ROTATING / STIMULATORY

  • MOTS → 2–3×/week
  • AICAR → training days
  • NAD → 2–4×/week
  • Cagrilintide → 1–2×/week

RECOVERY / SUPPORT

  • DSIP
  • ARA

HEAVY SIGNAL

  • FOXO → pulse only

⚠️ BIG PICTURE (WHY THIS WORKS)

Before: → stacked growth signals → water retention → nerve irritation → fatigue masked as “drive”

Now: → mitochondrial + metabolic + neuro balance → sustainable → cleaner energy → fewer side effects

THE REAL RULE

If performance drops → the system is wrong

Not:

  • weight
  • appetite
  • “feeling lighter”

Only:

  • output
  • recovery
  • repeatability

RP&D Disclaimer

This document is provided for educational and research documentation purposes only.

It does not constitute medical advice, diagnosis, or treatment.

All compounds discussed are referenced in a research context only.

Individual response, risk, legality, and appropriateness vary.

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