RP&D Overview
This stack is designed for lean muscle gain, improved training execution, controlled water retention, preserved insulin sensitivity, and recovery stability following prior androgen and IGF exposure.
This is not medical advice, not individualized guidance, and not intended for unsupervised use.
This document exists to track:
- timing
- dosing
- rationale
- vial math
- phase logic
Stack Duration
Total Length: 6 weeks
Context: Female athlete, post-Anavar → post-Tesamorelin + IGF lane
Goal: Resume growth without compounding fatigue, sleep disruption, or metabolic drift
① CORE GH LANE (DAILY)
Tesamorelin
- Dose: 2 mg
- Timing: Nightly, fasted, pre-sleep
- Why it’s here:
- Elevates endogenous GH
- Improves sleep architecture and recovery
- Supports fat partitioning during a bulk
- Why nightly only:
Aligns with natural GH pulse and reduces daytime water retention and carpal tunnel risk.
Ipamorelin
- Dose: 300 mcg AM + 300 mcg PM
- Timing:
- AM: fasted on waking
- PM: fasted, paired with tesamorelin
- Why it’s here:
- Clean GH pulses
- Minimal cortisol, prolactin, or aldosterone impact
- Lower water retention than aggressive GHRPs
② IGF LANE (TRAINING DAYS ONLY)
IGF-1 DES
- Dose: 30–40 mcg
- Timing: Fasted pre-workout
- Purpose:
- Local muscle signaling
- Satellite cell activation
- Exercise-specific hypertrophy signaling
IGF-1 LR3
- Dose: 30–40 mcg
- Timing: Post-workout, with carbohydrates
- Purpose:
- Systemic anabolic signaling
- Nutrient uptake into trained tissue
- Reinforces post-training growth window
PEG-MGF
- Dose: 1 mg
- Timing: 2× per week (leg days preferred)
- Purpose:
- Structural hypertrophy
- Muscle repair
- Long-tail growth signaling independent of insulin spikes
③ METABOLIC + ENERGY SUPPORT
MOTS-C
- Dose: 10 mg
- Frequency: 2–3× per week
- Purpose:
- Mitochondrial efficiency
- Exercise tolerance
- Improved fuel handling during a bulk
- Why not daily:
Intermittent signaling avoids cost waste and signal blunting.
NAD⁺
- Dose (titrated):
- Week 1: 100–150 mg per session
- Week 2: 150–200 mg per session
- Week 3+: 200–250 mg per session (if tolerated)
- Weekly total: 400–750 mg (cap)
- Purpose:
- Cellular energy production
- Nervous system resilience
- Recovery support
- Timing: Any consistent training or recovery window; avoid immediately pre-bed if stimulatory effects are noticed
- Frequency: 2–3× per week
- Cycle length: 6–8 weeks (default)
- Time OFF: Transition to Protocol ① or reduce to ≤1× weekly
- Notes: This is a phase, not a lifestyle. Benefits typically peak weeks 3–5.
④ NUTRIENT PARTITIONING (NON-APPETITE SUPPRESSIVE)
Retatrutide
- Dose: 2 mg once weekly
- Purpose:
- Improve nutrient partitioning
- Preserve insulin sensitivity
- NOT for appetite suppression
- Why weekly (not daily):
- Daily dosing risks appetite suppression
- Weekly dosing preserves metabolic efficiency without blunting intake
⑤ PRE-WORKOUT NOOTROPIC / MIND–MUSCLE STACK
Taken 30–45 minutes pre-training
Alpha-GPC
- Purpose: Acetylcholine support
- Benefit: Improved motor unit recruitment
L-Tyrosine
- Purpose: Dopamine support
- Benefit: Focus and drive under training stress
L-Theanine
- Purpose: Smooth stimulation
- Benefit: Reduces anxiety without sedation
Huperzine-A
- Purpose: Acetylcholinesterase inhibition
- Benefit: Extends acetylcholine activity, enhances neuromuscular signaling
Citrulline Malate
- Purpose: Nitric oxide support
- Benefit: Pumps and blood flow without CNS interference
Beta-Alanine
- Purpose: Intramuscular buffering
- Benefit: Improved high-rep and volume tolerance
What this stack is doing
- CNS clarity without overstimulation
- Stronger mind–muscle connection
- Pumps without extreme vasodilators
- Works with the GH/IGF environment, not against it
⑥ PRE-WORKOUT NEURAL DRIVE (PEPTIDE)
SEMAX
- Dose: 600 mcg
- Timing: 20–30 minutes pre-workout
- Purpose:
- Focus
- Motor control
- Execution quality
- Neural drive during training
- Why it’s included:
Better reps = better growth stimulus.
STACK SUMMARY — WHAT THIS SYSTEM IS DOING
- GH lane: recovery, sleep quality, fat control
- IGF lane: muscle-specific growth signaling
- MOTS-C + NAD⁺: energy + metabolic efficiency
- Retatrutide: nutrient partitioning without appetite suppression
- SEMAX + nootropic stack: execution quality → higher hypertrophy signal
This is a growth-first system with restraint, not a water-bloated blast.
VIAL REQUIREMENTS — 6 WEEKS
Assumptions
- 6 weeks = 42 days
- Training days = ~4–5/week (24–30 sessions)
| Compound | Vial Size | Usage Pattern | Total Needed | Vials | |--------|----------|---------------|-------------|-------| | Retatrutide | 20 mg | 2 mg/week | 12 mg | 1 | | Tesamorelin | 20 mg | 2 mg nightly | 84 mg | 5 | | Ipamorelin | 5 mg | 600 mcg/day | 25.2 mg | 6 | | IGF-1 DES | 1 mg | 30–40 mcg × training days | 0.72–1.2 mg | 1–2 | | IGF-1 LR3 | 1 mg | 30–40 mcg × training days | 0.72–1.2 mg | 1–2 | | PEG-MGF | 2 mg | 1 mg × 2/week | 12 mg | 6 | | MOTS-C | 10 mg | 10 mg × 2–3/week | 120–180 mg | 12–18 | | NAD⁺ | 500 mg | 50–100 mg/day | 2,100–4,200 mg | 5–9 | | SEMAX | 10 mg | 600 mcg pre-workout | 14.4–18 mg | 2 |
RP&D Disclaimer
This document is provided for educational and research documentation purposes only.
It does not constitute medical advice, diagnosis, or treatment.
All compounds discussed are referenced in a research context only.
Individual response, risk, legality, and appropriateness vary.
Consult a qualified professional before applying any protocol concepts.